Hello from Thailand, Mathew.
A client asked me this question online just 30 minutes ago, and I'd really value your opinion. We were chatting about the use of Andrographis paniculata as a prophylactic to boost immune response for those who need to travel in this covid-19 world. I cautioned my client to cycle the intake with periods of abstention, so as not to over exert his liver function.
Is there an optimal cycling ratio? X days on vs XX days off? Is that cycling ratio standard for "most" herbs and is there a basis from which it is calculated?
Curious. :)